Inflammatory Processes Associated with Canine Intervertebral Disc Herniation

Inflammatory Processes Associated with Canine Intervertebral Disc Herniation

Intervertebral disc herniation (IVDH) is an important pathology in humans and also in dogs. While the molecular disease mechanisms are well investigated in humans, little is known about the inflammatory mediators in naturally occurring canine IVDH. The objective of this study was to investigate whether the involved proinflammatory cytokines in human IVDH are also key cytokines in canine IVDH an...

Inflammatory profiles in canine intervertebral disc degeneration

BACKGROUND Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine and chemokine profiles in IVD degeneration in dogs, and mainly focused on gene expression. A better understanding is needed in order to develop biological therapies that address b...

Intervertebral disc herniation, spinal nociceptive signaling and pro- inflammatory mediators

Intervertebral disc herniation in adolescents.

BACKGROUND The purpose of this study was to review surgery-proven lumbar disc herniation in adolescents with an emphasis on the distinguishing features. METHODS Twenty-eight adolescents between 14 and 18 years old had lumbar discectomy after conservative treatment for 9 months. Indications for surgery were intractable pain and failure of conservative treatment for more than 6 weeks. Lumbar sp...

Intervertebral Disc Herniation: Pathophysiology and Emerging Therapies

Approximately 2.6 % of the US population visits a physician for treatment of spinal disorders annually (Fraser 2009 ) with costs of $7.1 billion from lost work days alone (Ricci et al. 2006 ) . “Herniation” of the intervertebral disc is one of the several spinal disorders that contribute to this very high incidence, with potential to cause signi fi cant pain, neurological de fi cit, and functio...